Benifits of Walking

â€Å"Benefits of Walking† Walking provides a wide range of benefits, some of which are more obvious than others. The obvious benefits of walking include the benefits to the individual from physical fitness and mental health improvements. A less obvious benefit is the way in which getting more people walking more often can help to generate a stronger local community, which in turn will contribute to happier and healthier neighborhoods. Every channel you turn to, every magazine you flip through, and every sports store you go to, shows the concept of exercising.Most people think of exercise as too much work. They make excuses like I don’t have enough time, or I’ll do it later. The purpose of this essay is to persuade my listeners to get out their walking shoes and start reaping the benefits of a healthy life and start walking. First we will discover how walking benefits our bodies, second uncover how easy it is to incorporate walking in to our daily lives, and thir d reveal the only equipment that one needs to take the first step putting one foot in front of the other.For many of us we are always finding ways to get out of exercising. Either we are too busy or we are putting it off until we have more time, but actually we never get the time to exercise and we just see ourselves jumping from a size 6 to a size 12. Well I have help for you. We were all born with 2 arms and 2 legs, so let’s put those legs to the use they were intended. Walking is one of the easiest forms of exercise and provides many health benefits.Regular walkers have fewer heart attacks and strokes, have lower blood pressure, and have higher levels of healthy HDL cholesterol than couch sitters do. In one study of women, a regular walking program did just as much in the heart-protection department as more vigorous exercise did. Thirty minutes of walking a day makes your muscles more sensitive to insulin. That allows glucose to do its duty inside your cells rather than pi le up in your bloodstream and cause other havoc.Even just a 5-minute walk cuts down on cigarette cravings. It engages your brain's emotion centers, unleashing mood-enhancing hormones that decrease cravings and take your mind off that cigarette. And establishing a walking habit proves to you that you have the discipline to stick with your stop-smoking plan. Physical activity nourishes brain tissue and stimulates its production of neurons, synapses, and blood vessels. Some studies have found that walking can counter faltering memories in people over age 50.Anyone who has come back from a walk in a different frame of mind than they went out with can attest to this. Studies back up that walking benefits your mood and may even ward off depression and anxiety. Not only can a walk perk you up when you need it, but also it helps improve the quality of your sleep, so you're more energetic all day long. Walking regularly can lower your risk of arthritis, macular degeneration, and even cancer by an astonishing 50% compared with people who don't exercise. Walking has the highest compliance rate of any exercise.

The Mall as Prison

Author David Guterson, journalist and novelist, spent a week in The Mall of America on assignment for Harpers Magazine. His essay, â€Å"The Mall as Prison†, tells his views on the Mall as a psychological effect on today’s society. He uses witty and sarcastic comments to get his point across. Is American culture being corrupted by what Americans consider a retail structure that is vital to the survival of our needs? He gives different aspects of why our view of a market place is distraction. Guterson makes judgments in this essay about the Mall and the American culture. Honestly I think that he needs to get with the times and accept this new evolution of shopping. Guterson starts with statistics and facts on the Mall as a retail complex. Opened in the summer of 1992, the mall was conveniently located close to the Minneapolis- St. Paul Airport. How ironically placed. He starts to question the Mall and it’s creators. Was this Mall a tourist attraction? Or a zone of entertainment that is easily accessible to all types of people? Being a male, I feel that Guterson does not fully appreciate the resources found in this mall. Therefore, this is why he reacting negatively to the Mall. This Mall was designed to not only be a mall, but to also be a tourist attraction that would draw a diversity of different people. Guterson talks about the look and atmosphere affecting the human psychology in the mind to think the situation was suitable. You should go into the mall with the intentions of shopping not with the intent of losing yourself in the mall’s design and structure. Guterson argues that communal areas should be built more for the intention of â€Å"eternal desire for discourse and intimacy†. Our society has lost our goals for what the marketplace should be. These goals cannot be accomplished in giant shopping malls, according to Guterson. Guterson’s only example of the types of people who enjoy shopping at the Mall, is a conversation that I feel is quite cliche and biased. He uses a conversation between two young women named Kathleen and Laura. The conversation is short but says a lot about the types of people who shop at the Mall. They explain that shopping to them is a â€Å"sickness† or a â€Å"drug†. Laura says: â€Å" Seriously, I feel sorry for other malls. They’re so small and boring. What does this idea say about today’s youth views on malls and their expectations? Do all malls have to be like The Mall of America? The fact that the Mall is so big, it gives it a special characteristic that no other mall can achieve. Not every trip to the mall has to be above and beyond. According to records, â€Å"Rural Americans traditionally looked forward to the excitement and sensuality of market day. † (Guterson 289) In the past, there were boundaries for market places. Today, anything entertaining is good enough. The Mall, according to Guterson, is not even a market place at all. He considers it a tourist attraction. The Mall is supposed to be greater than any other mall or tourist attraction. It is supposed to be both. The idea that The Mall of America is a cultural image is not even the word Guterson would use to explain this marvel. The mall has everything you would ever imagine in a theme park, mall, or institution. Anything from marriages to shootings happen in the Mall. Extreme malls aren’t stopping in just the United States. Japan is planning on building a $400 million dollar mall complete with an ice rink, a water park, a fantasy-theme hotel, three breweries, waterfalls, and a sports center. The concept of shopping will never cease. Every megamall will try and out-do the last. Malls of the world will continue to grow bigger and bigger. Who knew that a place with no windows or clocks would be so claustrophobic yet popular? Who knew that a place selling everything imaginable would be the one of many centers of the United States’ economy? Who knew that this fantasy of a megamall would stimulate something so powerful as to inspire psychological dependence to spending money? No one would have seen it coming. But now that its here, do we take it for granted? Do we abuse our rights as humans with free will? Guterson argues these points but does not make his conclusions clear. Ending in a sarcastic remark about the Mall’s theme park, â€Å"Camp Snoopy†, I feel he does not conclude his thoughts to his essay. As for the future of megamalls? They will never stop impressing the public eye. But Guterson believes that we need to stay on track with our priorities. Guterson explains, â€Å"I already knew that the Mall of America had been imagined by its creator not merely as a marketplace but as a national tourist attraction, an immense zone of entertainment. (Guterson 288) He sees the Mall as a distracting aspect of our society. Guterson makes judgment in this essay about the Mall of America and more broadly about American culture. He also talks about the building of The Mall of America as a tourist attraction and how the mall is degrading the art of architecture because it’s a waste of a building. Guterson has good credentials that make his opinion reliable, but I feel that he needs to look at the positive aspects that the Mall has for the economy and the United States wealth systems. His opinion is respected, but he needs to appreciate what megamalls have offered the world.

Science and Technology as the Engine of Economic Growth and Essay

Science and Technology as the Engine of Economic Growth and Development - Essay Example The creation of factories and new mills heralded increased opportunities for employment of ordinary working people and hence was largely, responsible for the rise of modern cities. Manchester was arguably the world’s first industrial city. In spite of the fact that Industrialization led to the population rise due to unprecedented reduction in the infant mortality rate the childhood surviving conditions did not improve (Mabel,1926).There was limited scope of education, and many children were forced to work at very low wages and harsh conditions. Eventually, being opposed to the child labor, many reform acts were framed by the government to stop exploitation of the working class. B. The period of Industrial Revolution witnessed the victory of middle class industrialists and businessman over the feudalists. Moreover, the scientific Revolution of 17th century resulted in development of international trade and creation of financial markets enhancing accumulation of capital. People started thinking to raise income and earn profits by entering into new privately owned business and professions. The advancements in mechanization of agriculture, factory system of manufacturing with powerful machines characterized by division of labor marked a global acceptance to the capitalist mode of production commonly known as Capitalism. (Burnham, 2003). C. The advent of industrial capitalism especially in the 19th century widened the socioeconomic gap between the working class and the industrialists. Unfair distribution of wealth and power, entrepreneurs’ tendency toward market monopoly; economic instability, unemployment and various forms of cultural exploitation were other connected issues that eventually led to the transformation of capitalism to communism (skilling, 435-451). 1. Capitalism is an economic system where the means of production and profit earned remained in the hands of private owners.

Volatility is the Saudi Arabian petrochemical industry Dissertation

Volatility is the Saudi Arabian petrochemical industry - Dissertation Example In the era of growing globalization, it is important to take appropriate steps for retaining one’s position amongst international competitors. This is the reason why Saudi Arabia, like many of its peers had been contemplating measures for expanding their respective productive capacities. However, Saudi Arabia is immensely dependent upon revenues from oil for its income which helps the country to stick to its strategic plans. Given the fluctuating nature of the same, it is essential to attach some certainty in the revenue figures in order to initiate a long term plan such as expansion of oil production capacity. A possible way through which this could be accomplished is that of attracting foreign direct investment funds. The national government has put forth a high degree of effort in this aspect recently, after the concept had been popularized and successfully implemented in Egypt from 2004. Normally private institutions are found to be more interested in adopting measures for encouraging FDI given their aim of instilling a more business-friendly environment and an edge over its peers. This is not the case in an economy which is crowded by public enterprises that does not move in the line of profit, which is why no such innovations had been entertained in Saudi Arabia. However, the national government having recently realized its mistake and has submitted to adopting measures for improving its productivity potential (New Zealand Trade & Enterprise, 2011). ). These statistics definitely speak out for the popularity.... Comparison between markets Returns and Stock Returns of Advanced Petrochemical Company 40 4.1.2 Alujain Corporation 40 Chart 2. Comparison between Market Returns and Stock Returns of Alujain Petrochemicals 41 4.1.3 Methanol Chemicals Limited 41 Chart 3. Comparison between Market Returns and Stock Returns of Methanol Chemical Company 42 4.1.4 Nama Chemicals Company 43 Chart 4. Comparison between Stock Returns of Nama Chemicals Company and Market Returns 43 4.1.5 National Industrialization Company 44 Chart 5. Comparison between Stock Returns of National Industrialization Company and Market Returns 44 4.1.6 National Petrochemical Company 45 Chart 6. Comparison between Stock Returns of National Petrochemical Company and Market Returns 45 4.1.7 Rabigh Refining and Petrochemicals Company 46 Chart 7. Comparison between Stock Returns of Rabigh Refining and Petrochemical Company and Market Returns 46 4.1.8 Sahara Petrochemicals 47 Chart 8. Comparison between Market Returns and Stock Return of Sahara Petrochemical Company 48 4.1.9 Saudi Arabia Fertilizers Company 48 Chart 9. Comparison between Market Returns and Stock Return of Saudi Arabia Fertilizers Company 49 4.1.10 Saudi Basic Industries Corporation 49 Chart 10. Comparison between Market Returns and Stock Return of Saudi Basic Industries Corporation 50 4.1.11 Saudi Industrial Investment Group 50 Chart 11. Comparison between Market Returns and Stock Return of Saudi Industrial Investment Group 51 4.1.12 Saudi International Petrochemical Company 52 Chart 12. Comparison between Market Returns and Stock Return of Saudi International Petrochemical Company 52 4.1.13 Saudi Kayan Petrochemical Company 53 Chart 13. Comparison between Market Returns and Stock Return of Saudi Kayan Petrochemical Company 53 4.1.14 Arabian

Major Theoretical Logic in Global Marketing Essay

Major Theoretical Logic in Global Marketing - Essay Example There is a major gap in our understanding of the types of internal organizational resources that are conducive to implementing a global marketing strategy and that can lead to sustainable competitive advantages in the global market. A major issue that needs to be investigated is what organizational processes that successful global competitors adapt to influence its foreign subsidiaries so that they can achieve global marketing standardization, coordination, and integration (Samiee and Kendall, 1992). Potential organizational processes may range from suggestion, inducement, request, to the direction (Bartlett and Ghoshal 1992). It should be interesting to know which process is more effective and, perhaps more importantly, under what conditions a particular process may be effective for implementing a global marketing strategy. Researchers need to properly conceptualize various organization processes, define their relationships to global marketing strategy implementation, and design emp irical studies to test such relationships. Another major issue involves the organizational structures that are conducive to global marketing strategy implementation (Appelbaum et al, 1998). While centralization vs. decentralization and product division vs. geographical division has received some discussion in the literature, other dimensions of organizational structure have not been investigated adequately. For example, how a firm's decision to enter into international joint ventures (or any other modes of foreign market entry) affects its ability to implement a global marketing strategy, and how various knowledge management systems relate to a firm's ability to implement a global marketing strategy are among important issues to be researched (Bellamy and Graham, 1987). Still another major issue in global marketing is the type of organizational cultures that facilitate global marketing strategy implementation (Beyers and Lindahl, 1999). Perhaps the strength of the organization cultu re is an important variable, or the content of the organization culture is more relevant. Researchers need to develop sound classification schemes for organization cultures and link them to a firm's ability to implement a global marketing strategy. Empirical research in this area is particularly scarce. In addition to the aforementioned issues that relate to a firm's internal organizational resources, research is also needed to identify various industry globalization drivers and the specific mechanisms through which a global marketing strategy can lead to competitive advantages for a firm. With quality research in these areas, a complete theory of global marketing strategy can be expected in the future. Culture is an important factor in the understanding organization because for any organization to operate effectively it must to some extent have a general set of beliefs and assumptions.  

North America, Latin America, The Caribbean and Sub-Saharan Africa are Essay

North America, Latin America, The Caribbean and Sub-Saharan Africa are Joined Economically and Culturally - Essay Example People from diverse backgrounds come together through the cyber-world, work together, socialize, discuss issues and keep themselves updated about whatever is going on through media. America is considered to be the world’s greatest global economy, especially the Northern region, which is a comprehensive mix of people from diverse backgrounds. The major global changes begin in this region of the world and then spread everywhere quickly owing to the numerous benefits of globalization. On the other extreme, there is Africa, where growth has been minimal throughout the years, which means that globalization was also at a bare minimum. In the middle of these two extremes lie Latin America and the Caribbean where globalization and growth were at a steady rate, much lesser than in North America but much higher than in Sub Saharan Africa. For instance, Mexico had a very high rate of globalization as compared to other Caribbean States. Africa is typically seen as a place where there is a severe lack of resources and, in extreme cases, people are dying of hunger. There are huge geographical and demographic differences amongst these regions, America being the greatest developed country and most regions of Africa being the least developed. There is a huge gap in resources, culture, eating habits, kind of jobs people do, level of living of people. Americans have a lavish style of living and mostly have service-based economies, while a part of Africa is still suffering from lack of resources and a fairly large percentage of people who do not have any way to make a living. They are less educated; and in America, education is a primary concern available to all.

Social work dessertation -Does Every child Matter Analysing policies Essay

Social work dessertation -Does Every child Matter Analysing policies around Young Unaccompanied asylum seekers in UK - Essay Example er, it should be noted, together with the global spread of capitalism (Cemlyn & Briskman, 2003), there has been also the spread of poverty, instability and war (Cemlyn & Briskman, 2003). The conditions of poverty, instability and war have resulted into the massive displacement of people. Adults as well as children are â€Å"displaced across national borders by armed conflict and political oppression†(Boyden & Hart, 2007: 237). This circumstance is aggravated by the reality that the violence against the displaced people is perpetuated by the state (Boyden & Hart, 2007). However, the suffering of the displaced people does not end there. As they flee from their country because it can no longer provide security and protection on their lives, property and liberty, they seek asylum on other countries wherein they are perceived as ‘outsiders’ who may be â€Å"encroaching on national assets however justified their claim†( Boyden & Hart, 2007: 237).This forced migra tion with which people are subjected includes children. The United Nations High Commission for Refugees (UNHCR), currently offers support to around 8 million refugee children (Boyden & Hart, 2007: 238). There is a tremendous increase in the number of asylum-seeking children since it is claimed that the contemporary shape of wars has changed in such a way that wars are now fought within the state, at the centre of the cities, at the very heart of the towns. Being such, there is an increase in civilian casualties which in turn gives rise to the â€Å"emerging demographic profile in much of the global South, where up to 50 per cent of national populations are currently under 18 years of age, it is inevitable that children constitute a large proportion of the peoples displaced by conflict† (Boyden & Hart, 2007: 238). In this regard, among asylum seekers, there is now the occurrence of unaccompanied asylum-seeking children. â€Å"Unaccompanied children leave their homes for diverse reasons: poverty and lack of

M1A2- Leadership and Ethics Assignment Example | Topics and Well Written Essays - 750 words

M1A2- Leadership and Ethics - Assignment Example The rumors were about the managing Director embezzle the company’s resources. To add on that, the aspect of mismanagement, where employees were not included in planning and the issue of ethnicity and racism was so much in practice. This caused a lot of unrest among the staff that the managing director went into hiding. The situation was so bad, that even the organizational output decreased tremendously. The breech in ethical principles and etiquette cost the organization a great deal, as they had to come up with strategies on guidance and counseling for all the staff members to reach and address the root cause of the problem. Hence, the inter relationship between values, morals and work ethics was established in a bid to solve the crises. According to Duska (1998), values refer to the definition of the good and bad in society. Moral values are those attributes that are upheld and valued in the society. Typical values include honesty, integrity, compassion, courage, honor, resp onsibility, patriotism, respect and fairness. By that definition, one could categorize the values listed above (honesty, integrity, compassion †¦) as â€Å"moral values† - values derived from a higher authority. When one acts in ways, which are consistent with our beliefs (whether secular or derived from a moral authority), we will characterize that as acting ethically. Hence, for one to be ethical, they need to posses ethics and moral values. According to Naagarazan (2006) the strategies to address the ethical crises apply in real life, whereby one attends therapy sessions and guidance and counseling in case, they face conflicts at home and the workplace. These tactics instill self-confidence in the individual, in that they are able to address and face their problems. This strategy is therefore effective in both the work place and real life situations. Reference List Duska, R. F. (1998). Education, leadership and business ethics: Essays on the work of Clarence Walton. K luwer Academic Publishers: Dordrecht Naagarazan, R. S. (2006). Textbook on professional ethics and human values. New Age International (P) Ltd., Publishers: New Delhi. A true leader should be able to address the specific organizational requirements while rendering his or her duties of ethical leadership. Discuss how you think virtues of character and leadership skills are acquired or developed within specific organizational contexts. For any given organizational framework, analyze parameters that will help you identify principles of best practice for leadership development. Identify and analyze attributes and competencies of effective leadership that can help implement these principles of best practice. Sucher (2008) wrote that, some of the leadership traits like humility, aggressiveness, and patience are innate, in that one is born a leader. They are nurtured in the day-to-day handling of the people in the organization. On the other hand, there are those traits that are acquired th rough practicing leadership for example, conflict resolution and team building. There are also those traits in leadership that are acquired through training, for example, listening and empathy skills from guidance and counsel ling classes, conflict resolution and team building from the managing people courses that people attend. Peterson & Sondergaard (2008) asserted that an organization that experiences effective ethical leadership, experiences high output. The staff on the other

An organisational case study Assignment Example | Topics and Well Written Essays - 1250 words

An organisational case study - Assignment Example Strategic formulation which is a key component of organizational entrepreneurship entails â€Å"the development of business mission, decisions both long term and short term objectives, and prioritizing strategies† (Karami, 2003). Dana (2004) notes that it is associated with deciding which resource is for what and in what amount, the process of entering international market or issues related to mergers with suppliers or sales agencies to diversify operations. Strategic formulation in business thus involves the perception of any strategy formulation process which has marked phases that are time-bound. Focus on Southwest Airlines This paper examines Southwest Airlines using SWOT Analysis in understanding its market penetration and product development strategic frameworks. It also draws the way forward for the airline to remain competitive. Bohm (2008) agrees that SWOT analysis has been used to evaluate and identify a number of areas in project formulation and Southwest is not an exception. The framework is used in mapping out the Strengths, Weaknesses, Opportunities and Threats. Indeed, it is used to formulate strategic plans and crafting solutions to control situations. All these predominantly follow an in-depth analysis of external environmental factors that affect the market and operations of Southwest Airlines (Bohm, 2008). ... outhwest Airlines One such is the organizational structure which focuses on the flow of information and responsiveness to client-related issues (Bohm, 2008). Southwest has often demonstrated quick response to client issues e.g. flight delays. Besides, the organizational organ gram is such that the pecking order is clear therefore the flow of information to those responsible in handling it is promptly facilitated for corrective action (Price, 2007; Mentges & Renga, 2010). Beyond this the strength in communication is further compounded by the fact that Southwest Airlines has an optimally utilized website. It was indeed one of the first airlines to have a fully fledged website to create widespread customer awareness on its services. However, one of the website’s weaknesses is that fares are not clearly outlined to enable customers make informed decisions just by the click of the mouse (Price, 2007). Regardless, it is reported that the airline has the largest pool of website visit s. It is also highly ranked with the best profitability record in the American market. The website also has a magazine that has caught the attention of many thereby bringing with it more customers (West, 2005; Joyner, 2006). In regards to the internet use Hoffman et al. (2001) believes that the company is on the right footing given that this is the information transformation age. The second way of examining internal analysis of strength and weaknesses is by looking into the organization’s planning. Daft (2008), states that the point is to examine the ‘feasible long and short term’ arrangement or map of action concerning for example the human resources. In this regards Southwest Airline is on top of its game. It also plans its flight operations well in advance and appropriately communicates

Teacher Professional Development and Student Achievement Gains Research Paper

Teacher Professional Development and Student Achievement Gains - Research Paper Example There are many options in developing the skills and knowledge of teachers. The most appropriate approaches to professional development aim at gaining high student performance. The research conducted on the professional development of teachers focus on the personal traits of teachers and classroom activities. Research helps to find the appropriate way of developing teachers so that students achieve high performance. This paper gives an analytical review of the teacher professional development, which is aim at increasing student learning and achievement. The activities and content, which must be included in teacher professional development, include student learning, skills of the teacher and the subject matter (Jogthong & Pimolbunyong, 2009). There are two categories of studies into the professional development and student achievement. The first category mainly focuses on the traditional teaching skills of teachers. The ability of a teacher in allocating adequate time for lessons is th e area of assessment so that the teacher adequately develops his or her ability to allow sufficient time for student learning (Frampton & Vaughn, 2003, p. 292). The development of the teacher therefore should focus on enabling the teacher to be able to apply critical thinking and taking all learning factors into consideration in allocating time for lessons. For example, the teacher should be able to allocate time for lessons depending on the level of education, abilities of students, and the nature of the subject he is teaching. In teacher professional development, the ability of the teacher to provide vivid demonstrations in class is an important consideration. This will enable the development of the skills of the teacher towards ensuring that he is able to provide illustrations and demonstration in class so that the understanding is a priority. This is more important in elementary education where learners require instruction aids such as photographs as a way of enhancing leaning a nd student achievement (Ross & Bruce, 2007). The content and activities, which constitute teacher professional development, also include determination of the ability of the teacher on the student comprehension or understanding during learning. For successful achievement of learning by students, learners must comprehend what the content of the lesson (Jogthong & Pimolbunyong, 2009). Assumption of the teacher that students have understood the content of the lesson may be wrong. As a result, the professional development of elementary school teachers must enhance the skills of the teacher and knowledge as a way of ensuring that he is able to know whether students comprehend the information on the topic of discussion. This will promote student learning because a professionally developed teacher will be able to know the areas of the class topic, which he should repeat or demonstrate further to enhance student understanding (Frampton & Vaughn, 2003). In professional development of teachers , the skills of the teacher in maintaining the attention are also part of the enhancement of the skills of the teacher (Spencer, 2007, 211). Students in the elementary school are easily distracted. The teacher should be able to maintain the attention of students if the achievement of the leaning objectives is to be possible. The decisions on the success of professional development should therefore emanate from the ability of the teacher to ensure that students focus on the lesson. If there are distractions, the teacher shou

Re-Branding Sunsilk Back Into the UK Hair Market Essay Example for Free

Re-Branding Sunsilk Back Into the UK Hair Market Essay Originally launched in the Netherlands in 1956, Sunsilk provides haircare solutions in 80 countries around the globe. No matter the hair type or problem, we have the products and the know how to make your hair feel and look beautiful. Our passion in life is to help women celebrate looking beautiful everyday, anywhere. Bad hair days are history Take on life with confidence and consign bad hair days to the bin with Sunsilk. Our range of products incorporates various natural ingredients and extracts with their own specific properties; chamomile for cleansing without limpness, ginseng extract for strength and more for any and all requirements. Get great advice and tips on hair care from us too. Key facts * Number 1 in Asia, Latin America and the Middle East * Sales of more than â‚ ¬1 billion a year * Sells in 80 countries * Also sold as Elidor, Hazeline, Seda and Sedal * Recent awards: Holds the Guinness world record for the most heads of hair washed and styled in one day Sunsilk is a hair care brand, primarily aimed at women, produced by the Unilever group, which is now considered the worlds leading company in hair conditioning and the second largest in shampoo[1]. Sunsilk is Unilever’s leading hair care brand, and ranks as one of the Anglo-Dutch conglomerates â€Å"billion dollar brands. Sunsilk shampoos, conditioners and other hair care products are sold in 69 countries worldwide. Sunsilk is sold under a variety of different names in markets around the world including Elidor, Seda and Sedal. The brand is strongest in Asia, Latin America and the Middle East and is the number one hair care brand in India, Brazil, Argentina, Bolivia, Bangladesh, Sri Lanka and Thailand. * 1954 – Sunsilk first launched in the UK.  * 1955 – First advertisement of Sunsilk appeared on TV. * 1964 – Launch of Sunsilk hair spray. * 1968 – Sunsilk shampoo re-packaged in PVC bottles. * 1971 – Launch of Sunsilk conditioner. * 1975 – Sunsilk became the biggest name in hair care. * 2003 – Sunsilk glossy magazine launched in Argentina. * 2008 – Social networking site Gang of Girls was introduced in India. First advertising Sunsilk began advertising in 1955 with a campaign that focused on specific hair issues. In the UK, the campaign focused on shiny hair. During the 1960s, a television commercial of Sunsilk featured a tune composed by John Barry, â€Å"The girl with the sun in her hair†, which proved so popular that it was subsequently released as a pop single. Sunsilk radio commercials were aired in 1969 featuring Derek Nimmo to support the new Sunsilk Herb shampoo for problem hair called â€Å"Hairy Tales†. In the early 1970s, Sunsilk was advertised with the slogan â€Å"All you need is Sunsilk†. Celebrity associations Madonna, Shakira, Marilyn Monroe, and Marian Rivera all featured in Sunsilks 2008 advertising campaign â€Å"Life Can’t Wait†[3] which launched with a Super Bowl XLII spot. The philosophy behind the campaign was about girls taking positive steps to gain better control of their lives â€Å"Hair On = Life On†. Actress and former Miss World Priyanka Chopra is the brand ambassador for Sunsilk in India. [4] In 2009, singer Delta Goodrem was announced as the face of Sunsilk in Australia. The singer and her music have since featured in several Sunsilk adverts.[5] In 2007, British girlband Girls Aloud launched a campaign for Sunsilk after securing a sponsorship deal worth over  £1,000,000.[6] Members Nicola Roberts, Nadine Coyle, Cheryl Cole, Kimberly Walsh and Sarah Harding all represented the brand, which included shooting a television commercial. Sunsilk also sponsored their following tour. Magazine In 2003, Sunsilk (Sedal) launched the first hair only glossy magazine in Argentina aiming to communicate to the professional hair industry. More than 800,000 copies are published each month. The magazine focuses on hair, fashion and beauty issues as well as showcasing hairdressers’ work. It is sold locally on news stands and distributed to hair salons. Gang of Girls In 2008, Sunsilk India launched a social networking site called Gang of Girls [7], which offered its users access to a variety of local and global experts to address various hair care needs through its content, blogs and live chat room. The site includes rich content of hair care and fashion, and users can also take part in interactive games and quizzes.In 2011, Sunsilk was listed in The Brand Trust Report published by Trust Research Advisory. Co-Creation collaboration From 2009 Sunsilk started working with a number of professional hair experts to develop new and improved products. Each hair â€Å"issue variant links to an expert† with the relevant specialist hair knowledge. For example, Dr Francesca Fusco, a New York dermatologist, co-created a â€Å"hairfall† variant for the brand. The line up also includes: Jamal Hammadi for Black Shine, Rita Hazan for Vibrant Colour, Teddy Charles for Plumped Up Volume, Thomas Taw for Damage Reconstruction, Ouidad for Defined Curls and Yuko Yamashita inventor of Japanese hair straightening process YUKO for Perfect Straight. Availability Sunsilk is available in over 60 countries worldwide. However Sunsilk products seem to be no longer available in the United States. The Sunsilk website has a list of countries where their products are sold, the USA is not one of them.

Health and Social Care within the British Welfare State

Health and Social Care within the British Welfare State The 1843 Poor Law was created because the middle and upper classes were coming to the conclusion that the local taxes they were paying were supporting the poor to be lazy and avoid work so many complained wanting a change to the current system. The new poor law sounded good as the poor and homeless would be sent to work houses being clothed and fed, even children would get some education there and they would have work for several hours a day. The work houses were not as accommodating as that; the people were treated as slaves, as if they were being punished for being poor and the work was hard and often dangerous. The workhouses would be an object of fear for the poor, families would be split up, they suffered from poor diets and any medical needs were not met. Many were outraged and spoke out against the poor law. Richard Oastler was one of those who spoke out against the poor law and fought for reform of the factories. He said: â€Å"I will use all my influence in trying to remove from our factory system the cruelties which are practiced in our mills. (Chaplin, A. 2009).† Anthony Ashley Cooper, 7th earl of Shaftesbury fought for factory reform for improved working conditions and in 1847 the changes to the factory act were improved and over the years kept improving to try and stop any worker being exploited. The great wars gave medical specialist a new image of stardom from the people of Britain because of their courage on the battle field and treating those back home. The first Great War praised the actions of the orthopaedic surgeon preforming impressive lifesaving medical procedures where ever they were needed. By World War 2 there were advances in medical, factory and motorised machinery leading to new challenges for medical professionals to deal with a new range of injuries. The orthopaedic surgeon now shared the limelight with other medical specialists now being recognised for their work. During the interwar years plastic surgeons were developing their skills and maintaining their specialist identity; their profession was now in high demand treating burn victims which was now an injury that affected a high amount of individual during WW2 because of the petrol driven means of transport; this also called for a high demand for burn specialists, cardiologists and thoracic surgeons who now had to treat patients who have been crushed by vehicles of war and machinery. A more modernised society was producing more ailments where the health care had to develop to meet the needs. The end of WW2 now recognised the importance of rehabilitation, this was not the situation after WW1 but now occupational therapists and physical medicines were sought after. The poor living conditions and the constant threat of danger caused a high number of soldiers and civilians to suffer with a psychiatric disorder and requested the need of psychiatric help. More than A third of military officers suffered with a mental disorder. WW2 created more opportunities for pathology as Penicillin ‘the miracle drug,’ cured wound infection, STDs and relieving a range of life threatening disease. The improved health of soldiers and gave them a morale boost and boosted the idea of creating more medicines to cure diseases. (Hardy, A. 2009) After 1945 Britain’s economy needed reconstruction so Britain wanted an influx of immigration labour. There was a large population growth which did lead to a shortage of social houses and from 1946 to the 1960s there was a baby boom leaving the system overwhelmed with the rapidly growing population. Sir William Beverage wrote the report Social Insurance and Allied Services in 1942 which became the blue print for the modern welfare state. â€Å"The Beveridge Report aimed to provide a comprehensive system of social insurance from cradle to grave. It proposed that all working people should pay a weekly contribution to the state. In return, benefits would be paid to the unemployed, the sick, the retired and the widowed. Beveridge wanted to ensure that there was an acceptable minimum standard of living in Britain below which nobody fell. (The National Archives. 2009).† â€Å"It was this report that identified the five ‘Giant Evils’ the government should fight namely: ‘Want, Disease, Ignorance, Squalor and Idleness. (Sir William Beveridge Foundation. 2012).† The public welcomed the idea with open arms and could not wait for it to be put into action but their current government the conservatives which was led by Winston Churchill missed his chance to ap ply any of the Beveridge report as he put all his focus on the war giving labour the chance to tell the public that they would implement this law if they were to get elected. In 1945 Winston Churchill lost the election even though his leadership helped win the war but it was not enough to keep him as prime minister because the British people were desperate for a better quality of life and equal health care, no longer have to go to struggling charity hospitals or only the working to be aloud treatment. (Addison, P. 2005). Labour now ran the country and led by Clement Attlee, his minister of health was Aneurin Bevan who would work hard to pass the national health act. Aneurin Bevan had a lot of opposition his main adversary was DR Charles Hill of the British Medical Association and organised a vote amongst all doctors to vote for or against the NHS, 85% were against and all those who were for were bullied for it and they created propaganda for the media to turn the public against the NHS. The doctors wanted to keep their status of independent contractors and not become civil servants. The working and middle classes were in support of the NHS, only 13% was on the side of the doctors. Aneurin gained support of Lord Moran the president of the Royal College of Physicians who controlled the consultants and the charity hospitals they were at this time destitute and Aneurin would support these hospitals with tax funding if he had support from his medical staff. The remaining doctors decided to join the NHS da ys before the start of the act as they realised all patients would be joining the NHS leaving their clinics soon to be empty. 1948 the National Health Act was implemented. The medical system realised how people were suffering with conditions who could not afford the healthcare. The hospitals were full and patience were requesting a lot of treatment as so many conditions were far gone they needed a lot of care even babies were in terrible conditions, before the NHS babies had a high mortality rate. (Rick, B. 2008). The NHS continued to improve and parliament discovers that it was impossible to cap its spending as medical techniques and equipment was always evolving. â€Å"Bevan foresaw this in speaking on 2nd June to a Royal College of Nursing conference. ‘We shall never have all we need, he said. Expectations will always exceed capacity. (Rivett. G. 2014)†. In 1965 there was an investigation into the local authorities in England and Wales; in 1968 this report was published by Fredrick Seebohm. He believed the current system was inadequate and a new more family orientated system should take its place and work for the individual and could work long term. He wanted it to be better than the current services but will be able to provide those services that are already available like â€Å"the childrens departments, the welfare services provided under the National Assistance Act 1948, educational welfare and child guidance services, the home help service, mental health social work services and other social work services provided by health departments, day nurseries, and certain social welfare work currently undertaken by some housing departments.† Local authorities should be able to assess a situation immediately and be able to provide for them out of what provisions they have in their own area. This improved social services department will be provided with training and staff will gain a social worker qualification and there will be specific jobs like field staff and residential staff. 11. (Seebohm, F. 1968). In 1970 the Local Authority Social Services act was implemented making it mandatory for every local authority to have a social services department and should adhere to the functions set by the secretary of state. The LASS act 1970 will work alongside the National Health Service Act 1946, the National Assistance Act 1948 and the Children Act 1948. Local authorities would also follow this act as they would their Health Visiting and Social Work (Training) Act 1962 and Health Services and Public Health Act 1968 and refer to all acts when to fulfil their authorities function. There is a 22 year difference between the NHS act and the LASS act this could be that before the NHS act the attitude of certain groups thought that the poor were a burden, brought their situation on themselves and even some G.Ps did not like to treat those in the slums. So health care was a priority to bring society to a stage of good health and good living conditions so social services could come in and have the provisions to work with and encourage wellbeing because the previous ill health of those who couldn’t afford to get it treated gave a low chance of living long lives for the working class. Social services would not be able to make their assessment if people were not able to be diagnosed by physicians or psychiatrists and a social worker does not have the medical training to diagnose a person and then people would go without help. Also working class and a high number of middle class were ill, suffering neglect from the state and malnourished if this was the norm in so me parts of Britain what could that area’s local authority do if the poor living conditions were that vast and what would be a case for social services to step in would be the how certain people had to live due to their financial status. In 1979 Margret Thatcher a conservative leader and a Neo-liberal became prime minister after winning the election against Labour as it was said their bad leadership lead to the country being in debt. Unlike her labour predecessors Thatcher opposed some of the ideas of the Beveridge report and reformed the NHS for it to become more of a market where the patients become customers and encouraged people to go private. She created the National Health Service act 1980 which promoted privatisation. This concerned the public who still wanted to keep their NHS the way it was but the waiting lists got longer and certain wards started to close. Health boards became purchasers and would have contracts with different medical drug companies to be able to purchase the best value for money. After Thatcher ‘the cradle to the grave’ ideology has not be looked back on. (BBC NEWS) The Barclay Report 1982 identified the unrealistic expectations of social workers and how society and the media would complain when these expectations were not met. Barclay saw two distinctive elements to social work: counselling and social care planning. He encouraged the idea of partnership between service users, families, statutory services and voluntary services and also to seek networks of care in the service users’ community. (Blewett, J. 1997) John Major was next after Thatcher in 1990 and continued with the reform of the NHS. Under conservative leadership â€Å"eight English Regional Health Authorities abolished from April 1996 and replaced by eight regional offices of a new NHS Executive, based in Leeds. Likewise, 100 new Health Authorities (HAs) replaced the previous structure of District Health Authorities and Family Health Service Authorities, the aim being to reduce bureaucracy and improve services. With no regional structure in Scotland, Wales and Northern Ireland, responsibility was left with health departments at national and local trust level. (BBC NEWS). â€Å" Labour comes back into power 1997 with Leader Tony Blair who believed in ‘the third way’. The third way’ or New Labour was the combination of the best features of the USA and Continental Europe economic dynamism and European social inclusion and bring them together. (Powell, M. 2008). Pressures from Scottish and Welsh Labour parties led to a political commitment by labour to transfer the powers from the Scottish office to a Scottish Parliament giving the ability to now pass primary legislation in those areas and from the welsh office to a National Assembly for Wales, administering and financing them within a frame work of Westminster legislation. Scotland and Wales now had the power to create health, education, housing and training department’s government by their own parliaments and Assembly and this system became a lot more organised. There are differences in some of the services of the NHS in other regions compared to England. In Wales and Scotland presc riptions are free but in England people are charged, ‘The National Institute for Health and Care Excellence’ is responsible for cost efficient medicines and equipment for England and Wales based but its ‘The Scottish Medicines Consortium’ that is in charge of that in Scotland and only in Scotland was the NHS car parking char abolished. (Hicks, R. 2013) Chancellor George Osborne gave his autumn statement 2014 sharing his plans for the NHS. Osborne has announced that he will be funding the NHS an extra 2 billion a year and a â€Å"new  £300m a year fund for kick-starting GP innovation†. The issue is is this too little too late, the NHS has been suffering for a while and is believed this extra money will be spend half way into the year on its shortfalls due to budget cuts. David Cameron quoted Thatcher by saying NHS spending was ‘safe in his hands’ but reports say the NHS has never been in such a worse state. Elizabeth Evans

Diagnosis And Treatment Of Haemoglobinopathies Biology Essay

Diagnosis And Treatment Of Haemoglobinopathies Biology Essay Haemoglobinopathy is a genetic inherited disorder. Haemoglobinopaty is associated to geographical distribution disease; it is most common in population of Africa, Middle East, Mediterranean, Asia and Southeast Asia. Haemogloninopathies are subdivided into two main significant genetic diseases thalassaemia and sickle cell disease. Transfusion treatment and bone morrow oar stem cell transplantation therapy use for treatment and management both diseases. But in sickle cell disease (SCD) there are some more treatment used as control the complication of disease such hydroxyurea, and vaccination against some pathogenic disease which are causes infection, and analgesic to relief the pain, and using prophylactic treatment against pneumococcal chest syndrome. Also the patient during the blood transfusion increased the amount of iron which is harmful for many organs in human body particularly the heart muscle tissue. In this case the patient need another therapy is iron chelation such as defer iprone with deferoxamine. The resent study declare that the most curative treatment and is bone marrow transplantation or stem cell transplantation. The most accurate test for haemoglobinopathy is including high pressure liquid chromatography (HPLC), haemoglobin electrophoresis (EP) and neonatal screening test and DNA parental test. Introduction Haemoglobinopathy is a genetic disease, associated with lack of normal haemoglobin in the red blood cells also the most common monogenic disease in the worldwide. Is inherited defect produce abnormal haemoglobin (Hb) in their structure, Hb playing an important role in red blood cells. This disorder is an autosomal recessive disorder. This disorder related to chronic haemolytic anaemia. (Marie and Fernando 2008) Haemoglobinopaty is geographical distribution disease; is most common in Africa, Middle East, Mediterranean, Asia and Southeast Asia. Also interaction between two genes among this people can causes to number types of thalassaemia disease, three aims for control are homozygous alpha-0 thallassaemia leading to Hb-Bart, homozygous beta-thalassaemia and beta-thalassaemia Hb-E. Hence that is important to detect very quick, immediate and accurate screening for prevention especially those parental are carrying the alpha-0 thalassaemia, beta-thalassaemia and Hb-E. (Fucharoen S et al 2 000) Haemoglobinopathy can spread in the many region of the world because of the mix ethnic and immigration from the countries which are prevalence the disease to non prevalence disease countries. Haemoglobinopathies occurs due to of the haemoglobins reduced their ability to carry the oxygen. This disorder associated to haemoglobin molecule disorder also that is important to understanding the structure and function of haemoglobin. There are two main types of haemoglobinopathy, SCD and thalassaemia can be passed from parental to offspring trough abnormal haemoglobin genes. Individual can be effect with these disorder while they are be inherited with two abnormal haemoglobin one from paternal and the other from maternal. But individual with only one abnormal haemoglobin gene called as carrier or trait, does not shows any clinical symptom and healthier as well. Individuals with haemoglobinopthies are either having clinical symptom of this disease, or if the individuals are carrier, unknown of their trait until screened, but If parent both carrier an abnormal hemoglobin gene there is a chance 25% of their pregnancy that offspring will affected with the clinical symptom of haemoglobinopathy If the maternal affected with haemoglobinopathy, and the paternal only carrier therefore the child 50% can be affected and 50% will carrier. The haemoglobin Hb molecule is a polymer consisting of four identical monomers. Hb molecule consist of two pairs of globins chains, each containing a haem group, every haem have an iron atom which is attached to oxygen in the lung and the haem which is responsible for transporting the oxygen from the lungs to the tissues and carrying the carbon dioxide (CO2) from the tissue to lung (Figure 1). For the period of foetus development, the foetal Hb predominate (two alpha chains and two gamma chains). Haemoglobin Hb molecule in adult composed of four globins chains two alpha subunit and two beta subunit. The structure Hb changes within embryonic, fetus and adult. Usually the main haemoglobin in normal adult is HbA, and little quantity of HbA2 and HbF. (Morven W et al 2009) Diagram showing the location of haeme in haemoglobin. Figure 1: shows the structure of haemoglobin (www.sciencelearn.org.nz) accessed 29/01/2011. Classification of heamoglobinopaties: haemoglobinopathy can divided into two main parts (figure -2) Thalassemia Sickle cell disease The name of referred object is cbr27_1p027f2.jpg Fig 2: (Ronald J 2006) Thalassemia Thalassemia is hereditary haemoglobin defect which failure the formation more than one polypeptide chain of haemoglobin protein causes mild or severe anaemia. thalassaemia classified into a few categories and each of them can causes different problems. Thalassamia is quantitative abnormality, frequently associated to chronic haemolytic anaemia, the clinical expression of disease including serious of haemolysis and some type of the disease not shows clinical symptom of the disease. Thalassaemia involved in the class of globins chain and number of defective of globins gene. The offspring with thalassamia at the birth frequently are healthy, the sign and symptom of anaemia appear in between age six month to two years old. Without detection and treatment the most of children in age one year old are death because of severe anaemia and infection. (Weatherall. D and Clegg. J 2001) Some types of thalassaemia initiate with mild condition, but some of them cases serious and life threatening and it cause death. Nearly 5% of the population in the nationwide have been affected with this disease. Foetal Haemoglobin (Hb) is predominantly alpha2 and gama2. In the normal individual the dominating haemoglobin composition is HbA i.e. alpha 2 and beta 2. This implies that the frequent forms of thalassaemia are alpha and beta, each type causes different clinical manifestation. Foetal Haemoglobin (Hb) is predominantly alpha 2 and gamma 2. In the normal individual the dominating haemoglobin composition is HbA i.e. a2b2. This implies that the frequent forms of thalassaemia are alpha and beta. (Fucharoen et al 2007) Alpha thalassemia: Individual with alpha-thalassemia characterised by lack of alpha globin chains. It is prevalence in Africa, Middle East, Asia, south east of Asia, and also Mediterranean area. The alpha-globin gene made up by four genes, found on chromosome 16p13.3 (Figure 4) and including the embryonic zeta-globins gene and two alpha globins genes, usually there are four alpha globins gene, mutation affected on one or more alpha-globins gene causes lack of formation of alpha- globin chain lead to alpha thalassaemia. (Weatherall. D and Clegg. J 2001) The patient with only one unusual alpha globin gene is called alpha thalassaemia carrier. In this case one globin genes defective or missing, and not show any clinical symptom of anaemia, and difficult to diagnosis also known as silent carrier. Normal carrier has an offspring with haemoglobin H (HbH). It is can be to detect by DNA examination. If the individual has missing two of four globin genes call as alpha thalasaemia trait, both abnormal alpha-globin genes can be found on one chromosome or one on each chromosome. The parents both have alpha thalasaemia trait therefore their offspring effective with alpha thalassaemia trait. The patient with this disease has mild anaemia and the red cells are smaller the normal size call microcytosis. And the patient does not show the clinical manifestation. (Leung. W et al 2008) Also if one of the parents has alpha thalassaemia trait and the other one has silent carrier there is 25% chance of their offspring born with HbH. But if the both parent have alpha thalassaemia trait there is 25% chance their offspring inherited with alpha-thalassaemia major. Individual with condition has no chance to live for long term and mostly die in childhood, the reason for that because of lack or defects of the alpha globin chain and causes the severe anaemia and causes health damaging such as spleenomegaly, bone malformation and tiredness. Beta-thalassemia: The beta-thalassaemia is an inherited disease associated with haemoglobin disorder, is congenital anaemia, occur because of lack or reduce formation of beta-globin chain causes reduce the number of red cells or produce unfunctional red cells, most of erythrocyte are failure to mature from the bone marrow that is cause serious anaemia. The beta- globin chain deficit causes the intracellular precipitation and increases of alpha-globin chain, leading to ineffective erythropoiesis and haemolysis anaemia. (Ronald J 2006) Beta-thalassaemia is the most common molecular deficiency as the consequence of point mutation and deletion that effect the transcription and mRNA translation. Infants with homozygous beta-thalassaemia are healthy but after birth as the haemoglobin from fetus replaced to adult haemoglobin the absent of beta-globin causes the serious anaemia. Also the level of anaemia is deference rely on the level of beta-globin deficiency and the formation of fetal haemoglobin. (Lin. Y e t al 2009) The clinical manifestations of beta-thalassaemia including of anaemia shows in the first year of life, also the spleen enlargement resulting from accumulation large amount of destruction os erythrocyte in the spleen, growth of bone marrow because the body compensated the red cells destruction which is leading to abnormal growth the long bones and deformation the skull. Beta-thalassemia is most prevalence in the Asia, and became the main health problem among people. (Weatherall. J 2001) In developing countries the patients with this disease are suffering and death within childhood. The recent study of the national thalassemia register reveals that the patients survive for longer in the UK, half population of patients with beta-thalassemia die under the age of 35 years old. Sickle cell disease (SCD) SCD is genetic defected haemoglobinopathy characterised by stiffen shaped cells which can block blood vessels and caused severe pain, organ damage and infection. Was found at the beginning the twentieth century, is an autosomal dominant genetic disorder, it is related to qualitative globin gene defect, and formation of abnormal globin chain, SCD results in morbidity and mortality. There are 500 unusual Hb found but only four of them are common such as HbS (beta 6 glu-val), HbC (beta 6 Glu-Lys), HbD (beta 87 Thr-Lys), HbE (beta 26 Glu-Lys). The disease is characterized by abnormality in shape of RBCs, the cell become sickle-shape which is rigid and stiffen and can leading to obstruction the blood vessels and tissue ischemia, which causes the organ damage. Also this abnormality can cause painful episodes, severe infection and chronic anaemia. SCD is the mutation in the haemoglobin gene and causes sickling the cells, mutation increased in different part of the Hb molecule, SCD can be de tected through infant screening haemoglobin electrophoresis. SCD occur because of mutation on short arm of chromosome 11 (figure-4), this mutation leading to replace the valine to glutamine of the amino acid at the sixth positions of beta-globin chain of HbA, resulting in the production of HbS which is biochemically unstable molecule and it can precipitate at the deoxygenated state. (Hoffbrand. A.V. 2001) chromos Figure- 4 Globin encoding genes are found on chromosome 11 and 16. Figure 3 SCD was the first disease has been described as a molecular disorder in a gene, and it is detected by infant screening program. Its causes reduce lifespan and associated to chronic disease. SCD occur in that part of the world where Plasmodium Palciparum has endemic and then spread because of migration to other part of the world for example north of Europe and United States. SCD is more common in those people are originally came from the Africa, Mediterranean, middle and south of America, Asia and middle east. (Figure 4) SCD occurs due to the newborn inherited the defect haemoglobin gene from parental mother and father HB SS causes severe anaemia, if only one sickle haemoglobin gene from one parent and one normal haemoglobin gene from other parent transfer to infant, therefore the infant become a carrier also known as sickle cell trait. (Marie. J and Ronald. L 2004) Image Reference: Marie. J and Ronald L 2004 Figure 5: Geographical distribution and representation of the sickle gene. (A) Map identifies the three distinct areas in Africa and one in the Arab-India region where the sickle gene is present (dotted lines). Numbers of individuals with sickle-cell disease (red lines) in Senegal, Benin, and Bantu are higher near the coast, and falls concentrically inland. (B) The ÃŽÂ ²-globin gene cluster haplotype is determined by DNA polymorphic sites (boxes) that are identified by endonuclease enzymes. With this information, haplotypes are constructed as shown. The pathophysiologies of CSD rely on the deoxy- HbS. That is association with two alpha globin chains with mutation of 2 beta-globin chains produce HbS. under deoxygenating circumstance, the lack of a polar amino acid at six locations of beta-globin chain lead to aggregation of Hb, which change the RBCs into sickle shape and reduced their elasticity. (Figure 5) The patients with the SCD are often visiting to hospital because of acute pain, and the patient treated by an analgesic to relief the pain, hydration and oxygen supply. The main common of clinical symptom of SCD including anaemia, episode painful, lung infection, infarctions of nervous system and strokes, spleenenlargment because of precipitation of large amount of haemoglobin in spleen, skin ulceration, organ damage, vaso-occlusive, and neurocongenitive dysfunction most common causes morbidity among the patient with this disease. Figure- 5: Normal and sickle red cell morphology SCD is known as chronic inflammatory disease, Diagnosis of haemoglobinopathies: Detection and identification of haemoglobinopathies relay on three stages: Full blood count Special haematological test DNA analysis Full blood account Full blood account is used to detection of haemoglobinopaty specially the thalasaemia, which is the earliest of haematological information. Individual with thalassaemia shows low mean corpuscular volume (MCV) or mean corpuscular haemoglobin (MCH). Also in other anaemia for example the iron deficiency the MCV is low as well, it is possible this detection will shows the thalassaemia in those region with at high risk ethnic populations. The first step after initial abnormal blood count is to elimination of iron deficiency, to cure it. The blood count test is repeated if the MCV still lower than normal value. The test show most likely is thalassemia. Also the MCV increased because of some condition especially B12 and folic deficiency causes raised the MCV. In some condition the main evidence of thalassaemis disappears due to the MCV is wrongly normal or may be increased. Measuring the MVC is used as early stage test for heamoglobinopathy. Therefore that is very important for diagnosis of thalassaemia this is the HbS carrier, the health professionals who are dealing with those people in which HbS occurs must be including the HbEPG with the demand a full blood count. Also blood film as part of full blood count can be used, it is detected the SCD (HBS) or unstable Hb. in some cases, finding the target cells and stippling in the blood film are not associated with a haemoglobinopathy but it can help as additional finding in case of thalassaemia if the MCV or MCH is lower than reference range. Special haematological test Some of test of haemoglobinopathy technically require skill the team of laboratory, must have knowledge and must be trained to use the laboratoryà ¢Ã¢â€š ¬Ã¢â€ž ¢s instrument, and obtain an experience in understand the results. More haematological test is requiring especially after detecting the more unusual HbS. Also test the oxygen affinity, stability of haemoglobin and identify the methaemoglobin. Mass spectrometry is used to characterise different mutation of HbS.( 10 )for diagnosis of individual cases is the DNA test. DNA test is the most common haematology test, due to the DNA laboratory must to understand the characterised of alpha and beta globin genes. As DNA technology in haemoglobinopathy based on PCR (polymerase chain reaction) and southern blotting, also the DNA laboratory examination deciding whether there is a point mutations or deletions. Other major source of mistake to deceive the DNA laboratory is the not a success to detection HbH. Not occasionally, a DNA detection used to diagnosis the beta globin gene due to HbH inclusion was not be found, if not mutation in DNA sequencing is detected, at this point the DNA laboratory back to the haematology test to detected the HbH inclusion. Another useful test to diagnosis a thalassaemia and it is because of an alpha and beta globin gene problem in the alpha and beta globin protein fraction. That is requiring to incubation of RBC with radioactive. The peaks indicative of alpha and beta globins are then provide an alpha and beta ratio which must equal one. If the ratio higher than one that is indicates beta thalassaemia, or if the ratio lower than one that is indicates alpha thalassaemia. The alpha and beta ratio is not longer available. That was took place due to DNA testing is became the common test and also alpha and beta ratios are now performed in those laboratory do have insufficient skill. Setting up of this assay needed fresh radioactive material. The alpha and beta ratio may be not useful while the interactions of genes are occurring. DNA testing DNA testing is requiring if the haemoglobinopathy difficult to detect by the haematological test, while it is may be suspected a haemoglobinopathy, but the haematology may not detected which gene has been involved. And the other reason to use DNA testing is the basic alteration been sought in an established haemoglobinopaty. This require as part of parental developed. (Ronald J 2006) DNA test can be used for sickle cell in neonatal by analysing of the DNA of foetal tissue Screening test for thalassaemia and haemoglobinopatphies Usually the basic screening trial all type of thalassaemia depends on the guide of haematology cut- off, which effects on the correct count using an automatic blood cell counter. The patient with MCV values lower than (80 fL), and MCH values lower than (27 pg). Therefore more tests are requiring identifying of (alpha and beta) thalassaemia. (Kanokwan, S et al 2005) But the test needs an expensive an automatic blood cell counting but that is impossible to perform in the laboratory without good facilities. Also that has been proved the osmotic fragility test tube which is containing 0.36% of saline solution could be used as like other option test to detected alpha and beta salassaemia syndrome. (Kamala. R 2008) The recent study indicated that specificity of the osmotic fragility test for detection of (beta and alpha-0) thalassaemia could be improved by reduce concentration of saline solution from 36% to 34%. But the carrier of Hb-E would not be available; in this case cichlorophenolindophenol (DCIP) test has been established for detection of Hb-E in the developing country of Southeast Asia, but this procedure is not suitable for pregnant woman because they have iron deficiency during their pregnancy. Hence the combination osmatic fragility test and DCIP test use for detection alpha,0- thalassaemia, beta thalassaemia and Hb E in pregnant woman tested and compared with other measure screening procedure linked to measure of RBCs indicator. (Kanokwan, S et al 2005) There is some more special haematology tests require to diagnosis of haemoglobinopathies: Hb EPG test can be measured by electrophoresis of globin. Different methods likely as gel and membrane based to high pressure liquid chromatography (HPLC). Unusual group separate as of normal HbA, HbF and also HbA2 can be detected.that dose mean provides some information about HbA2, and recognize some other Hb if available for example HbE and HbS. HbA2 test is detected by globin electrophoresis and quantity the HbA2. And difference methods are used as a membrane, also the more use in the world is HPLC. That does mean the increased HbA2 shows the incident of beta- thalassaemia. It dose shows that the alternative haemoglobins could be increased the HbA2. Also unusual raised the HbA2 shows the mild beta thalassaemia, the low HbA2 delta thalassaemia. HbF test detected by globin electrophoresis, and determine by deference technique. The normal value in of HbF adult is lower than 1%, if the HbF slightly increased to 2 or 3% that indicates the mild beta- thalassaemia. If HbF elevated to more than 5% are likely to be delta-beta thalassaemia in this case the level of HbA2 decreased. (Angela. H 2005) Kleihauer test is staining the red cell to diagnosis the HbF. This test uses for separate the hetrocellular from pancellular. This test is unusual for differentiation the type of hereditary persistence of Hbf because they are not often available and difficult for laboratory staff to translate the results. This test useful only in foetal blood sample to detect that the HbF passed from the fetes to the motherà ¢Ã¢â€š ¬Ã¢â€ž ¢s blood circulation. (Liu. W et al 2007) HbH inclusion test carry out by stain the red blood cells to identification of HbH inclusion, deposition of beta globin chain. This test used to detection of alpha-thalassaemia. This test causes problem due to false negative. Need a lot of knowledge and skill of laboratorian to detect HbH inclusion and with two gene deleted alpha-thalasaemia, only very HbH little inclusion can be detected. Therefore the laboratorian may miss it if do not have good experience. Must the person who is work in the laboratory must continuously look at the microscope. (Chan. A 1996) Sickle solubility and stability test, there many different type of test performed to detected the HbS or unstable variation of HbS. There are interactions between the HbS with beta thalassaemia, hence the correct test for sickling test are require for haenoglobinopathy. (Baebara J 2004) RBC count can be used for detection of thalassaimia and haemoglobinopathies while the red cells count is normal or increased. Also it is helpful if hypochromic, microcytic observed. The Red cell Distribution Width (RDW) is a numerical value that represents the coefficient of variation of the red cell volume distribution. This value indicates the variation in red cell size (anisocytosis). Anisocytosis is an abnormally of red cell size variation that is apparent on the blood smear, is the anisocytosis is increased that is indicated the beta and alpha thalassaemia as it is seen before the haemoglobin decreased and MCV and MCH reduced. Mean Cell Haemoglobin Concentration (MCHC) it is the other parameter is the concentration in g/L of haemoglobin in the RBC, But It is infrequently measured. If the MCHC reduced that is shows the hypochromic with any other causes microcytosis that is indicates the thalassaemia. Haemoglobin electrophoresis for diagnosis of CSD Diagnosis SCD can be performed by the haemoglobin electrophoresis. Simple and accurate method for diagnosis of SCD due to in can detect the Hbs, but the EP is reliable to identify the phenotype. Sickle cell test the sodium metabisulphite used for remove the agent leads to precipitate in the buffer solution to formation the cloudy suspension. This test is not useful neonatal period because of lack HbS and presence high amount of HbF which has high solubility and may generate false negative result. Sickle cell test can be used after six month of age becouse the level of HbF dropped down. For distinguish the phenotype should relying on the haemoglobin electrophoresis. Separation of molecule in this test rely on the charge at add pH. H Methods: There same key words have been used to find the journals which are related to finding the information for the topic of the project. The key words including (haemoglobinopathies, Thalassaemia (beta or alpha), Sickle cell disease, treatment of haemoglobinopathies and diagnosis of haemoglobinopathies). Treatment for thalassaemia More than 90% of the patient with thalassaemia needs to be treated by regular blood transfusion to regulate the anaemia and its side effects, transfusion therapy increase the life span of patient with quality of life. Infants who are sufficient treated by blood transfusion growth well. However the transfusion therapy causes increased the amount of iron in the organ, iron overload is fatal if untreated causes organ damage, late sexual growth, and osteoporosis. Most individuals with beta-thalassaemia major can be survive for longer with blood transfusion therapy but increasing the damaging levels of iron overload if the patient not be treated with iron chelation therapy. Increased the level of iron from blood transfusions therapy leading to destruction the macrophages and then follow that damaging the liver and later on spreads to the heart tissue, pancreas, and also the iron overload effected on the same of glands such as pituitary, thyroid and parathyroid glands, the levels of iron must be controlled by chelating treatment. Due to the blood transfusion are usually started at the beginning in life, excess of iron effects on the endocrine system can causes unusual growth and hypogonadotrophic hypogonadism. Cardiac disease is the most causes of death among the patient with beta-thalassaemia major. Iron overload causes reduce the myocardial T2 vales is detected by cardiac magnetic resonance imaging, is prevalence in the patient with beta-thal lassaemia. (Kirk P et al 2011) Iron chelating therapy supports the patient with increased the level of iron from the accumulation the toxic iron and reduce the amount of iron that harmful for tissue and many organs. Iron chelating initially used by the end of the 1970s, it is not a curative for the patient with beta-thalasaemia major but it can reduce the number of death because of this disease. The patient with this has some side effects which are related to excess iron such as diabetes, hypogonadism, and hyper thyroidism, (Rugolotto S et al 2004) The main purpose of using the iron chelation is sustain the balance of amount of iron at the safe stage in the organ tissue and stop accumulating of iron inside the organ. To reduce the level of iron in body, there are deference ways to rescue the human body from iron overload. Venesection is procedure, part of treatment. Used to withdraw large amount of blood a through the vein and discarded, use for treatment of iron overload also is known by phlebotomy used for elimination of iron in the blood circulation, removes 200-250mg iron from unit of blood. Also the iron chelating can help the patient to reduces the level of iron, iron chelation with deferoxamine causes the damaging of tissue and ultimately causes death, the resent study explore that the cardiac disease is causes death in more than 70% of patient who are treated with deferoxamine. The new oral chelater was started in 1995; oral chelater with deferiprone became very useful treatment in the clinical therapy. The prospective non randomized clinical test proved that the mortality because of the cardiac disease decreased in patient treated with deferiprone, combine and sequential the deferiprone with deferoxamine. (Aurelio. M et al 2009) The diagnosis laboratory performed the experiment on 265 patients in one of the Italia laboratory from year 2000 to 2008, 124 patients treated deferoxamine and 11 patient was death, and 55 patients treated with deferiprone none of them death, 68 patients treated with sequential deferiprone and deferoxamine only one patient death and 18 patients treated with combine deferiprone and deferoxamine none of them death. This trial give clue the best treatment for iron chelating is deferoxamine or combination between deferiprone and deferoxamine. Figure 6: trial profile 265 patient treated with iron chelater.

The Healing Power of Music Essay example -- Music and the Brain

In December of 1992, David Ott’s father was dying of cancer. On Christmas Eve morning he went into a coma. The family gathered in the small hospital room knowing that their beloved husband and father would not be with them long. Since it was Christmas Eve, carolers were going through the hospital quietly singing. As they walked past the room singing â€Å"Silent Night†, a single tear fell across the comatose man’s cheek. His family stated that after seeing him just lay there all day without moving, that the single tear was his way of telling them goodbye. Ott stated that â€Å"music can go where words cannot† (Griffen). Research shows that music is to the brain as physical exercise is to the human body. Some form of exercise is necessary for a healthy body. People know what to do to tone their body but do they exercise their minds regularly and properly? Do they know that listening to Mozart can help increase their memory? Music has a greater impact on hum an lives than we think; it assists in releasing or creating strong emotions, strengthens the brain increasing the ability to learn, and has the power to heal. Music has a larger affect on feelings and emotions than most people realize. It is an automatic response for the human body to react to music in certain ways. Miller explains that â€Å"By the age of five, almost all healthy children have developed an unconscious framework for listening that will form the basis of their emotional response to music.† Sometimes the emotion that the music brings is very noticeable. For example, if someone is attempting to recover after the death of a loved one and they hear a song that reminds them of that person it can create different emotions quickly. The song could make that person remember the good ... ...The Australian 2011: 3. Newspaper Source Plus. Web. 14 Oct. 2015. Millar, Aaron. "Music & Emotion: Why Do Sad Songs Make Us Cry?" Odyssey 22.7 (2013): 14. Middle Search Plus. Web. 1 Oct. 2015. Munz, Michele. "Music Support Program for Teen, Young Adult Cancer Patients." St. Louis Post-Dispatch (MO) 26 Sept. 2013: Newspaper Source Plus. Web. 13 Nov. 2015. â€Å"Music Therapy as a Treatment Modality for Autism Spectrum Disorders.† Music Therapy. American Music Therapy Association. June 2012. Web. 14 October 2015. O’Donnell, Laurence. â€Å"Music and the Brain.† Music Power, N.p., 1999. Web. 8 October 2015. Sacks, Oliver. Musicophilia: Tales of Music and the Brain. New York: Vintage Books, 2008. Print. Weinberger, Norman M. â€Å"Music and the Brain.† Scientific American Special Edition 16.3 (2006): 36-43. Health Source- Consumer Edition. Web. 10 Oct. 2015.

Crushed Dreams in The Glass Menagerie Essay -- Glass Menagerie essays

Crushed Dreams in The Glass Menagerie      Ã‚  Ã‚   Tennessee Williams is known for his use of symbols, tension, and irony. Williams uses all of these components to express the central theme of The Glass Menagerie - hope followed by despair. Each of the characters has dreams that are destroyed by the harsh realities of the world.      Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   As the narrator blatantly admits, 'since I have a poet's weakness for symbols', symbols are central to The Glass Menagerie (Williams 30). Symbols are merely concrete substitutions used to express a particular theme, idea, or character. One major symbol is the fire escape which has a separate function for each of the characters. This fire escape provides a means of escape for Tom from his cramped apartment and nagging mother. Therefore, the fire escape for him represents a path to the outside world. For the gentleman caller, the fire escape provides the means through which Jim can enter the Wingfield apartment, thus entering their lives. For Amanda, the fire escape allows Jim to come into the apartment and prevent Laura from becoming a spinster. The significance of the fire escape for Laura is that it is her door to the inside world in which she can hide. It is ironic that when Laura does leave the security of her apartment, she falls. This symbolises Laura's inability to function properly in the outside world.      Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Another recurring symbol is the glass menagerie which represents Laura's hypersensitive nature and fragility. Laura is just as easily broken as a glass unicorn - and just as unique. When Jim accidentally bumps into the unicorn and breaks it, the unicorn is no longer unique. Likewise, when Jim kisses Laura and then shatters her hopes by telling her he's eng... ...ructure of the entire play -   an ironic pattern of romantic expectations, momentary fulfilment, and ultimate loss' (Thompson 13).    Works Cited and Consulted Bloom, Harold. Introduction. Tennessee Williams. Ed. Harold Bloom. New York: Chelsea House, 1987. 1-8. King, Thomas L. "Irony and Distance in The Glass Menagerie." In Tennessee Williams. Ed. Harold Bloom. New York: Chelsea House, 1987. 85-94. Levy, Eric P. "'Through Soundproof Glass': The Prison of Self Consciousness in The Glass Menagerie." Modern Drama, 36. December 1993. 529-537. Thompson, Judith J. Tennessee Williams' Plays: Memory, Myth, and Symbol. New York: Peter Lang, 1989. Williams, Tennessee. The Glass Menagerie. In Literature: An Introduction to Reading and Writing, 4th ed. Ed. Edgar V. Roberts and Henry E. Jacobs. Englewood Cliffs, NJ: Prentice Hall, 1995. 1519-1568.    Crushed Dreams in The Glass Menagerie Essay -- Glass Menagerie essays Crushed Dreams in The Glass Menagerie      Ã‚  Ã‚   Tennessee Williams is known for his use of symbols, tension, and irony. Williams uses all of these components to express the central theme of The Glass Menagerie - hope followed by despair. Each of the characters has dreams that are destroyed by the harsh realities of the world.      Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   As the narrator blatantly admits, 'since I have a poet's weakness for symbols', symbols are central to The Glass Menagerie (Williams 30). Symbols are merely concrete substitutions used to express a particular theme, idea, or character. One major symbol is the fire escape which has a separate function for each of the characters. This fire escape provides a means of escape for Tom from his cramped apartment and nagging mother. Therefore, the fire escape for him represents a path to the outside world. For the gentleman caller, the fire escape provides the means through which Jim can enter the Wingfield apartment, thus entering their lives. For Amanda, the fire escape allows Jim to come into the apartment and prevent Laura from becoming a spinster. The significance of the fire escape for Laura is that it is her door to the inside world in which she can hide. It is ironic that when Laura does leave the security of her apartment, she falls. This symbolises Laura's inability to function properly in the outside world.      Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Another recurring symbol is the glass menagerie which represents Laura's hypersensitive nature and fragility. Laura is just as easily broken as a glass unicorn - and just as unique. When Jim accidentally bumps into the unicorn and breaks it, the unicorn is no longer unique. Likewise, when Jim kisses Laura and then shatters her hopes by telling her he's eng... ...ructure of the entire play -   an ironic pattern of romantic expectations, momentary fulfilment, and ultimate loss' (Thompson 13).    Works Cited and Consulted Bloom, Harold. Introduction. Tennessee Williams. Ed. Harold Bloom. New York: Chelsea House, 1987. 1-8. King, Thomas L. "Irony and Distance in The Glass Menagerie." In Tennessee Williams. Ed. Harold Bloom. New York: Chelsea House, 1987. 85-94. Levy, Eric P. "'Through Soundproof Glass': The Prison of Self Consciousness in The Glass Menagerie." Modern Drama, 36. December 1993. 529-537. Thompson, Judith J. Tennessee Williams' Plays: Memory, Myth, and Symbol. New York: Peter Lang, 1989. Williams, Tennessee. The Glass Menagerie. In Literature: An Introduction to Reading and Writing, 4th ed. Ed. Edgar V. Roberts and Henry E. Jacobs. Englewood Cliffs, NJ: Prentice Hall, 1995. 1519-1568.   

Ray Charles Robinson Essays -- Soul Music Biography Musician Essays

Ray Charles Robinson Ray Charles Robinson, more commonly known as Ray Charles (to avoid confusion with boxer Sugar Ray Robinson), was born in the southern city of Albany, GA on September 23, 1930. He was a prolific, multi-talented singer, pianist, bandleader, and composer who, when on stage captivated his audience not only by his musical ability, but also because he was a blind, African American man. He was given the nickname â€Å"the Genius† for his capability of combining the music of gospel, jazz, pop, country and rhythm and blues (R&B), known as â€Å"soul music.† Charles began going blind at around age five, and had completely lost all eye sight by age seven. The cause of his blindness was never confirmed, but most believe it was due to glaucoma. By then, his family had moved to Greenville, FL, and Charles had already begun playing the piano. Charles’ mother never took pity on him, she began teaching him things even before he became completely blind. He never saw his being blind as a weakness, and that helped him out tremendously as a child and into adulthood. He soon began attending the St. Augustine School for the Deaf and Blind, as a charity student, where he perfected his piano skills while learning how to play various other instruments. He also learned how to read and write music, type, and compose scores in Braille. Both of Charles parents were dead by the time he was fourteen, and at age fifteen he was orphaned and left St. Augustine to begin his professional music career. For almost two years, he played for local bands in Florida, but then he headed to Seattle, WA which has been said to be the turning point in Charles’ personal and professional career. During the ear... ...lobe Award nominations. Works Cited "Charles, Ray." Encyclopedia Britannica. 2005. Encyclopedia Britannica Online. 22 Jan. 2005 < http://search.eb.com/eb/article?tocId=9022591&query=RAY%20CHARLES&ct= >. "Charles, Ray." Encyclopedia Britannica. 2005. Encyclopedia Britannica Online. 22 Jan. 2005 < http://search.eb.com/ebi/article?tocId=9310645&query=RAY%20CHARLES&ct= >. Ray Charles: The Official Site. Comp. Chad Hanson, Ira Merrill, and Raenee Robinson. Mar. 2001. RCR Production, Inc. 22 Jan. 2005 < http://www.raycharles.com/ >. "Ray Charles." Ed. Larry Sanger, and Jimmy Wales. Wikipedia: The Free Encyclopedia. 15 Jan. 2001. Wikipedia Online. 22 Jan. 2005 < http://en.wikipedia.org/wiki/Ray_Charles >. The History of Rock 'n' Roll. Comp. D K. Peneny. Mar. 1998. 22 Jan. 2005 < http://www.history-of-rock.com/ray_charles.htm >.

Series 7 Study Guide

Chapter 13 Investment Company ( ) Investment Companies A corporation or trust in which investors pool their funds and are usually organized as corporations in the same manner as any other business corporation. However, some have been established as trusts and as such are supervised by trustees rather than dir ? Diversification Advantages of Investment ? Professional Management Company ? Liquidity The basic legistration governing investment company and difines and classifies investment companies into 3 basic types. ? Face Amount Certificate Company The Investment Company Act of ?Unit Investment Trust(UIT) 1940 ? Management Company The Act requires all investment companies with 100 shareholders or more to register with the SEC. A public offering may not be made by a mutual fund until it has a minimum net worth of $100,000. New shares are registered by the fund periodically, usually Type of Investment Companies Face Amount Certificate Issues debt certificates offering a predetermined ra te of interest. Holders are entitled to redeem Company their certificates for a fixed amount on a specified date.Investment companies with no management fee and low sales charges that invest in a fixed Unit Investment portfolio of municipal or corporate bonds are categorized as UIT. The funds are issued in book (UIT / ) entry form and registered form. Established under an indenture or simil Manage a portfolio of securities in accordance with specified investment objectives. Each day, usually at the end of trading on the NYSE, a management company will determine the value of its Management Company portfolio or the net asset value(NAV) per share. ? Closed-end ? Does not issue redeemable shares ? Open-end ?Issues redeemable shares Usually capitalizes through a 1-time public offering of shares and may issue commom stock, Closed-end Investment preferred stock, or bonds. The company does not continuously issue shares nor will it redeem its Company shares. The market price of closed-end funds will be based on the f Also called mutual fund. They are continuously issuing new shares which they stand ready to Open-end Investment Company redeem. All shares issued are common shares ONLY. Instead of 5% policy, sales charge will be applied. Management(investment advisory) fees are normally the largest Chapter 13Types of Mutual Funds Diversified Common Stock Funds Income Funds Balanced Funds Bond Funds Money Market Funds Bonds and Preferred Stock Funds Specialized Funds Operation of a Mutual Fund Board of Directors Investment Companies Consists mostly of common stocks. The funds can have a variety of investment objectives. One might be conservative and invest primarily in blue-chip stocks. Another might be more aggressive and invest primarily in growth stocks. Have as their investment objective high current income. Maintain some proportion of their assets in bonds and preferred stock as well as in common stock.Invest their assets solely in bonds and have as their objective stability of income. Invest in short-term debt(money market) instruments. A typical money market fund invests in CP and CDs. They generally pays the interest to the investors monthly. Invest in senior securities, both bonds and preferred stock. Their objective is current income with safety of principal. Invest a large proportion of their assets in a particular industry such as the chemical industry. Elected by the mutual fund shareholders and are responsible for developing and implementing investment policies.According to the Investment Company Act of 1940, at least 40% of the board of directors must be unaffiliated with the mutual fund. Unless authorized by majority vote of its shares, an investment company may not; ? Go from diversified to non-diversified ? Change its investment objectives and concentration of investments ? Borrow money, underwrite securities issued by others, make loans, buy or sell real estate ? Change the nature of business so as to cease acting Must be sent to stockholders semiannually. Mutual funds sell ex-dividend whenever the fund or its principal underwriter(sponsor) determines.The ex-dividend date for a mutual fund is usually the same day as the record date. Contracted by the fund to issue new shares and cancel redeemed shares for the fund. Normally also in charge of the disbursement of dividend and capital gain distributions and performing other bookkeeping. Responsible for the safekeeping of the securities owned by a mutual fund. Mutual funds must have a national bank, trust company or other qualified institution act as its custodian. He holds the cash and securities of the fund but does NOT perform any mana The principal underwriter of the fund.He has an exclusive agreement with the fund which allows him to purchase fund shares at the current NAV. The shares may then be resold to the public, through outside dealers or the sponsor's sales force, at the full Shareholder Rights Financial Report Dividend of Mutual Fund Transfer Agent Custodian Sponsor(Distributor) Chapter 13 Section 12b-1(The Investment Company Act of 1940) Investment Companies Though a sponsor is used and bears the cost of sales of literature and other promotional items, under certain situation, selling expenses may be borne by the fund. Chapter 13 Dealers Investment CompaniesMust have a signed selling agreement with the sponsor. They are fobidden to purchase mutual fund shares for inventory. But they can do so only to fill customer orders or for their own investment. If a dealer who has purchased shares for investment decides Manages the fund's portfolio. Re. management of a mutual fund, securities on margin, participate in a joint account, or sell short securities may not be permitted in general. Investment advisory contracts must be approved by a majority of the fund's share Total Expense / Average Net Assets NAV + Sales Charge = NAV / (100% – Sales Charge Percentage) = $10. 0 / (100% – 7%) = $10. 75 Total Net Asset / Number o f Shares Outstanding Orders to buy and sell the fund are based on the next price to be computed. Sales Charge / Public Offering Price = $1. 57 / $19. 60 = 8% Based on public offering price. According to the NASD's Conduct Rules, the maximum allowable percentage is 8. 5%. In the sale, there is no sales charge though is redemption fee(i. e. 1%). To charge the maximum 8. 5% sales charge, the mutual fund must offer i To be sold to the public at the NAV, without any sales charge added. No-load fund may charge a liquidation fee when an investor sells the fund.Dollar levels at which the sales charge is reduced. Amount Deposited Sales Charge Percentage Less than $10,000 8. 5% $10,000 – $25,000 7. 5% $25,000 – $50,000 6. 0% Enables an investor to qualify for the discount made available by breakpoints without initially depositing the entire amount required. LOIs are NOT binding on the investor and only available to single purchaser. The letter states the investor's intention T hose people who are eligible for sales breakpoints and LOI, which includes a joint account only between husband and wife.Partnership, investment clubs and joint accounts are NOT eligible for reduced sales charges or LOI. Investment Advisor Expense Ratio Buying Mutual Fund Shares Public Offering Price(Asked Price) Net Asset Value(NAV / per share) Buy and Sell the Fund Sales Charge Percentage No-load(N. L. ) Funds Breakpoints Letter of Intent(LOI) Single Purchaser Chapter 13 Voluntary Plans Dollar Cost Averaging (Constant Dollar Plan) Dollar Averaging Redeeming Mutual Fund Shares Redemption Investment Companies Require an initial minimum investment.The investor will indicate an intention to invest a minimum amount at fixed intervals, such as montly or quarterly. Fixed dollar amount is invested periodically. Fixed share amount is invested periodically. Redemption fee is calculated based on NAV. Mutual funds are required under the Investment Company Act of 1940 to pay the proceeds of re demption within 7 calendar days. The SEC can order or allow, upon the request of a fund, that redemption be suspended fo ? Fixed-dollar Types of Withdrawal Plans ? Fixed-percentage ? Fixed-share Taxation of Mutual Fund Distributions Earnings for Investment ?Investment income(dividends & interest on the securities) Companies ? Capital gain Investors will receive a Form 1099 to report distributions for income tax purpose. They may elect to Form 1099 take distributions from mutual funds in the form of reinvested shares rather than in the form of cash. Investment Income Dividends & interest on the securities. Taxable to the investors as ordinary income. When an asset is sold for more than its cost, the result is a capital gain. ? Long-term gains ? Result from the sale of assets held for more than 1 year / taxed as capital gain Capital Gain ? Short-term gains ?Result from the sale of assets held for 1 year or less / taxed as ordinary income Capital gains are taxed at the individual's tax rate, up to a maximum of 20%. Holders of one fund in the group may have an exchange or conversion privilege allowing them to Exchange Privilege convert to another fund of the same manager at the NAV. Investment companies can avoid paying taxes on income since they are eligible for special tax Taxation of Investment treatment under Subchapter M of the Internal Revenue Code. This special tax treatment is called Companies the â€Å"conduit† or â€Å"pipeline† treatment.Avoid triple taxation which would occur if the mutual fund paid taxes. The companies held in the fund's portfolio pay corporate income taxes and the investor pays taxes on dividends received from the fund. Therefore, taxes payable on dividends and interes Conduit / Pipeline Chapter 13 Conduit / Pipeline Investment Companies Corporatoi n in Portfolio Mutual Fund Dividen Investors Regulated Investment Companies The investment companies that meet certain requirements under Subchapter M are considered to be re gulated investment companies. Chapter 13 Reporting Requirements 300% Asset CoverageInvestment Companies Annual report must be sent to the SEC and semiannual reports must be sent to the shareholders. Investment Company Rules and Regulations Management companies(open-end & closed-end) are subject to 300% asset coverage to control their leverage, therey reducing risk. NASD Rules on Investment Companies Selling Fund Shares NASD members may not purchase fund shares at a discount from an underwriter unless the underwriter is also an NASD member. This effectively restricts non-member underwriters from distributing their shares through NASD firms. NASD members must transmit payApplied to the practice of inducing an investor to purchase a mutual fund on the basis of an impending dividend. The investor was induced to buy the stock based on the impending dividend. However, had the investor waited until ex-dividend date, the price Occurs when a registered representative does not inform a custom er about the availability of a Breakpoint Sale sales breakpoint or a LOI. The Anti-Reciprocal Rule of the Prohibits member firms from selling open-end investment company(mutual fund) shares because NASD of commissions received or to be received from the investment company.An underwriter of investment company shares is prohibited from giving a member firm any Special Deals discount above the one specified in the selling agreement for the sale of the shares. If a RR retires, he or she may continue to receive commissions for sales of investment company Continuing Commissions periodic payment plans initiated prior to the retirement if there was a bona fide contract with the person's firm to receive such commissions. Selling Dividends Chapter 13 Investment CompaniesInvestment Company Advertising and Sales Literature SEC Rule 134 Permits the publication of a simple ad describing the basic features of a new issue. Permits the use of ad that describes, in general terms, how investment compa nies work. The SEC Rule 135A communication must be limited to information re. investment companies in general, or to the nature of investment companies. Permits the publication of an investment company ad that satisfies the definition of a prospectus SEC Rule 482 under certain conditions. This ad may NOT contain an application ot invest in the investment company.SEC Rule 156 Sales Literature Real Estate Investment Trust(REIT) Tax Treatment Difference between Appreciation & Capital Gain Warns that sales literature would be considered misleading if it 1)contained an untrue statement of material fact, 2)omitted a material fact that was necessary to make a statement not misleading. Any sales literature re. redeemable investment company securities must be filed with the SEC within 10 days of use. Similar to an investment company but is not considered to be a type of investment company.He manages a portfolio of real estate oriented investments to earn profits for investors. To qualify as a REIT, a company must be set up as a domestic corporation m REITs are the favorable tax treatment given under the REIT Act Amendment to the Internal Revenue Code of 1954. If 95% of the ordinary income generated from the portfolio is distributed to investors, REIT is taxed only once. Appreciation : An increase in the market price of a security from the purchase price. Capital Gain : Recognized when the security is sold and the appreciation is realized.